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Thesis

(-)-Indolactam V and MO47: reducing heterogeneity in human iPSC culture

Abstract:

The induction of induced pluripotent stem cells (iPSCs) presents a paradigm shift for cell therapies, disease modelling, drug screenings and toxicology. Notably, the first clinical trials are attempting to bring iPSC derived therapy from bench to bedside. Consequently, the demand for iPSCs has seen a considerable surge, and thereby incentivised the scale- up from 2D to 3D culturing systems. Current iPSC culture in 2D is contact-dependent. This gives rise to a lack of uniformity in iPSC cul...

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Department:
Department of Pharmacology / Blavatnik School of Government

Contributors

Department:
Department of Engineering Science
Role:
Examiner
Department:
Department of Chemistry/Pharmacology
Role:
Supervisor
Department:
Department of Chemistry
Role:
Supervisor
Department:
Ludwig Cancer Research Centre
Role:
Supervisor
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford

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