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Endothelin-1 increases superoxide production in human coronary artery bypass grafts.

Abstract:

AIMS: Endothelin-1 (ET-1) has been shown to increase endothelial superoxide (O(2)(-)) production in experimental animal models. It is unclear whether ET-1 increases O(2)(-) production in humans. We sought to elucidate whether ET-1 increases O(2)(-) production in human vessels and to identify the mechanism behind this effect. MAIN METHODS: Segments of internal mammary artery (IMA) and human saphenous vein (HSV) were harvested from 90 patients undergoing elective coronary artery bypass graft su...

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Publication status:
Published

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Publisher copy:
10.1016/j.lfs.2012.03.024

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Volume:
91
Issue:
13-14
Pages:
723-728
Host title:
Life sciences
Publication date:
2012-10-01
Event location:
Netherlands
DOI:
EISSN:
1879-0631
ISSN:
0024-3205
Source identifiers:
132199

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