Endothelin-1 increases superoxide production in human coronary artery bypass grafts.

Conference item

AIMS: Endothelin-1 (ET-1) has been shown to increase endothelial superoxide (O(2)(-)) production in experimental animal models. It is unclear whether ET-1 increases O(2)(-) production in humans. We sought to elucidate whether ET-1 increases O(2)(-) production in human vessels and to identify the mechanism behind this effect. MAIN METHODS: Segments of internal mammary artery (IMA) and human saphenous vein (HSV) were harvested from 90 patients undergoing elective coronary artery bypass graft su...

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Authors: Cerrato, R; Cunnington, C; Crabtree, M; Antoniades, C; Pernow, J

• Publication status: Published
• Host title: Life sciences
• Volume: 91
• Issue: 13-14
• Pages: 723-728
• Publication date: 2012-10-01
• Event location: Netherlands
• DOI: 10.1016/j.lfs.2012.03.024
• EISSN: 1879-0631
• ISSN: 0024-3205
• Keywords: Coronary Artery Disease; Saphenous Vein; Peptides, Cyclic; Endothelin-1; Coronary Artery Bypass; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Humans; Luminescent Measurements; Female; Middle Aged; Oligopeptides; Piperidines; Aged; Superoxides; Receptor, Endothelin A; Male; Mammary Arteries; Onium Compounds; Receptor, Endothelin B