Diversity within the pRb pathway: is there a code of conduct?

Journal article

The failure of cell proliferation to be properly regulated is a hallmark of tumourigenesis. The retinoblastoma protein (pRb) pathway represents a key component in the regulation of the cell cycle and tumour suppression. Recent findings have revealed new levels of complexity reflecting a repertoire of post-translational modifications that occur on pRb together with its key effector E2F-1. Here we provide an overview of the modifications and consider the possibility of a 'code' that endows pRb ...

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Authors: Munro, S; Carr, S; La Thangue, N

• Publication status: Published
• Journal: Oncogene
• Volume: 31
• Issue: 40
• Pages: 4343-4352
• Publication date: 2012-10-01
• DOI: 10.1038/onc.2011.603
• EISSN: 1476-5594
• ISSN: 0950-9232
• Language: English
• Keywords: Ubiquitination; Cell Cycle; Apoptosis; Retinoblastoma Protein; Signal Transduction; Phosphorylation; Cell Proliferation; Protein Processing, Post-Translational; Methylation; Humans; E2F1 Transcription Factor; Acetylation