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Human immunodeficiency virus-specific CD8(+) T-cell responses do not predict viral growth and clearance rates during structured intermittent antiretroviral therapy.

Abstract:

There is a continuing search for better ways to use existing drugs against human immunodeficiency virus (HIV). One idea is to use short therapy interruptions to "autovaccinate" HIV-infected patients. A group of 13 chronically HIV-infected patients enrolled in a trial of such so-called structured treatment interruptions (STIs) were intensively studied with respect to their viral load (VL) and HIV-specific CD8+ T-cell (cytotoxic T-lymphocyte [CTL]) responses. We found that 10 of the 13 patients...

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Publication status:
Published

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Authors


Oxenius, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Fischer, M More by this author
Dawson, SJ More by this author
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Journal:
Journal of virology
Volume:
76
Issue:
20
Pages:
10169-10176
Publication date:
2002-10-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:572185b1-0674-4eff-ad10-944c4ef85259
Source identifiers:
21165
Local pid:
pubs:21165

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