Increase in Na+/K+ pump numbers in vivo in healthy volunteers taking oral lithium carbonate and further upregulation in response to lithium in vitro.

Journal article

1. We have measured [3H]-ouabain binding to lymphocyte membranes in eight healthy volunteers before and after they had taken lithium carbonate for 14 days in doses which maintained the serum lithium concentration in the range 0.5-1.0 mmol 1-1. 2. There was a statistically significant increase in the [3H]-ouabain binding capacity of the lymphocyte membranes (reflecting the number of Na+, K+-ATPase molecules) after 14 days of lithium administration in vivo. This suggests that a failure to incre...

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Authors: Antia, I; Dorkins, C; Wood, A; Aronson, J

• Publication status: Published
• Journal: British journal of clinical pharmacology
• Volume: 34
• Issue: 6
• Pages: 535-540
• Publication date: 1992-12-01
• DOI: 10.1111/j.1365-2125.1992.tb05659.x
• EISSN: 1365-2125
• ISSN: 0306-5251
• Language: English
• Keywords: Humans; Up-Regulation; Adult; Lymphocytes; Male; Cells, Cultured; Ouabain; Administration, Oral; Lithium Carbonate; Sodium-Potassium-Exchanging ATPase; Tritium