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Journal article

Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells.

Abstract:

Dendritic cells (DCs) are potent antigen-presenting cells that initiate protective T-cell immunity in mice. To study the immunogenicity of DCs in humans, we injected 9 healthy subjects subcutaneously with a control injection of autologous monocyte-derived, mature DCs, followed 4-6 weeks later by DCs pulsed with keyhole limpet hemocyanin (KLH), HLA-A*0201-positive restricted influenza matrix peptide (MP), and tetanus toxoid (TT). Four more subjects received these antigens without DCs. Injectio...

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Publication status:
Published

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Publisher copy:
10.1172/jci6909

Authors


Dhodapkar, MV More by this author
Steinman, RM More by this author
Fossella, C More by this author
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Journal:
The Journal of clinical investigation
Volume:
104
Issue:
2
Pages:
173-180
Publication date:
1999-07-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:5703d098-f04c-4315-b781-78a7c32adbba
Source identifiers:
31524
Local pid:
pubs:31524

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