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Journal article

An arterial-specific enhancer of the human endothelin converting enzyme 1 (ECE1) gene is synergistically activated by Sox17, FoxC2, and Etv2.

Abstract:

Endothelin-converting enzyme-1 (Ece-1), a crucial component of the Endothelin signaling pathway, is required for embryonic development and is an important regulator of vascular tone, yet the transcriptional regulation of the ECE1 gene has remained largely unknown. Here, we define the activity and regulation of an enhancer from the human ECE1 locus in vivo. The enhancer identified here becomes active in endothelial progenitor cells shortly after their initial specification and is dependent on ...

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Publication status:
Published

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Publisher copy:
10.1016/j.ydbio.2014.08.027

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Oxford Ludwig Institute, BHF Centre of Research Excellence
Role:
Author
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Journal:
Developmental biology
Volume:
395
Issue:
2
Pages:
379-389
Publication date:
2014-11-05
DOI:
EISSN:
1095-564X
ISSN:
0012-1606
URN:
uuid:570307e7-5275-4daa-b4fa-c8980065eec9
Source identifiers:
483503
Local pid:
pubs:483503

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