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Thesis

Genome-wide mapping of the hypoxic response

Abstract:

Hypoxia regulates many hundreds of genes with important roles in ischemic and neoplastic disorders. Central to this response are the hypoxia inducible transcription factors (HIF). This work aimed to better understand the direct transcriptional response to HIF by mapping HIF-binding sites across the genome using chromatin immunoprecipitation coupled to high-throughput sequencing (ChIP-seq). ChIP-seq for HIF in MCF-7 breast cancer cells under hypoxic conditions revealed more than 400 high-st...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Research group:
Prof. Peter Ratcliffe
Oxford college:
Brasenose College
Role:
Author

Contributors

Division:
MSD
Department:
Doctoral Training Centre - MSD
Role:
Supervisor
Division:
MSD
Department:
Doctoral Training Centre - MSD
Role:
Supervisor
Division:
MSD
Department:
Doctoral Training Centre - MSD
Role:
Supervisor
More from this funder
Funding agency for:
Schödel, J
Grant:
088182/Z/09/Z
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:5701c6b5-f397-4b21-a66b-cfc02043fe40
Local pid:
ora:7143
Deposit date:
2013-08-02

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