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Thesis

Genome-wide mapping of the hypoxic response

Abstract:

Hypoxia regulates many hundreds of genes with important roles in ischemic and neoplastic disorders. Central to this response are the hypoxia inducible transcription factors (HIF). This work aimed to better understand the direct transcriptional response to HIF by mapping HIF-binding sites across the genome using chromatin immunoprecipitation coupled to high-throughput sequencing (ChIP-seq). ChIP-seq for HIF in MCF-7 breast cancer cells under hypoxic conditions revealed more than 400 high-st...

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Institution:
University of Oxford
Research group:
Prof. Peter Ratcliffe
Oxford college:
Brasenose College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Centre for Cellular and Molecular Physiology
Role:
Author

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Supervisor
Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Dr. med. Johannes Schödel
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:5701c6b5-f397-4b21-a66b-cfc02043fe40
Local pid:
ora:7143

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