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Measurement of pre- and post-synaptic proteins in cerebral cortex: effects of post-mortem delay.

Abstract:

Assessments of synaptic density in human brain are often based on measurements of synaptic proteins. Little information is available on their post-mortem stability. We have investigated this by ELISAs of the pre-synaptic proteins syntaxin and synaptophysin, and the post-synaptic protein PSD-95, in rat and human cortex. The rat brains were cooled in situ from 37 to 20 or 4 degrees C over 3 h, and then kept at 20 or 4 degrees C for a further 24-72 h, to simulate post-mortem storage at room temp...

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Publication status:
Published

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Authors


Dawbarn, D More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Journal:
Journal of neuroscience methods
Volume:
139
Issue:
2
Pages:
153-159
Publication date:
2004-10-05
DOI:
EISSN:
1872-678X
ISSN:
0165-0270
URN:
uuid:56f93f4f-1a29-4c38-8f2a-038575af42a1
Source identifiers:
32879
Local pid:
pubs:32879

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