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7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase.

Abstract:

7-Deazaxanthine (7DX) was identified as a novel inhibitor of thymidine (dThd) phosphorylase (TPase). It inhibited the TPase reaction in a concentration-dependent manner. At 1 mM, it almost completely prevented the TPase-catalysed hydrolysis of dThd to thymine. The 50% inhibitory concentration (IC50 of 7DX was 40 microM in the presence of 100 microM of the natural substrate dThd. 7DX is also endowed with a marked inhibitory effect on angiogenesis. It significantly prevents neovascularisation i...

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Publication status:
Published

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Journal:
FEBS letters
Volume:
438
Issue:
1-2
Pages:
91-95
Publication date:
1998-10-01
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Language:
English
Keywords:
Pubs id:
pubs:31042
UUID:
uuid:56f4e9ae-edc1-410c-8531-501deaab58d9
Local pid:
pubs:31042
Source identifiers:
31042
Deposit date:
2012-12-19

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