Journal article
7-Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase.
- Abstract:
-
7-Deazaxanthine (7DX) was identified as a novel inhibitor of thymidine (dThd) phosphorylase (TPase). It inhibited the TPase reaction in a concentration-dependent manner. At 1 mM, it almost completely prevented the TPase-catalysed hydrolysis of dThd to thymine. The 50% inhibitory concentration (IC50 of 7DX was 40 microM in the presence of 100 microM of the natural substrate dThd. 7DX is also endowed with a marked inhibitory effect on angiogenesis. It significantly prevents neovascularisation i...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- FEBS letters
- Volume:
- 438
- Issue:
- 1-2
- Pages:
- 91-95
- Publication date:
- 1998-10-01
- DOI:
- EISSN:
-
1873-3468
- ISSN:
-
0014-5793
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:31042
- UUID:
-
uuid:56f4e9ae-edc1-410c-8531-501deaab58d9
- Local pid:
- pubs:31042
- Source identifiers:
-
31042
- Deposit date:
- 2012-12-19
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- Copyright date:
- 1998
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