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Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomised controlled trial.

Abstract:

Because treatment with third-generation cephalosporins is associated with slow clinical improvement and high relapse burden for enteric fever, whereas the fluoroquinolone gatifloxacin is associated with rapid fever clearance and low relapse burden, we postulated that gatifloxacin would be superior to the cephalosporin ceftriaxone in treating enteric fever.We did an open-label, randomised, controlled, superiority trial at two hospitals in the Kathmandu valley, Nepal. Eligible participants were...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/s1473-3099(15)00530-7

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine, Viet Nam
Role:
Author
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Funding agency for:
Baker, S
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Funding agency for:
Baker, S
Wellcome Trust More from this funder
Li Ka Shing Foundation Global Health Programme More from this funder
Publisher:
Lancet Publisher's website
Journal:
Lancet Infectious Diseases Journal website
Publication date:
2016-01-20
DOI:
EISSN:
1474-4457
ISSN:
1473-3099
URN:
uuid:56ea0d6e-a11f-4a6c-8198-1748a7d34c51
Source identifiers:
597885
Local pid:
pubs:597885
Language:
English

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