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Journal article

Ras as a target in cancer therapy.

Abstract:

Ras proteins are guanine nucleotide-binding proteins that are central to the control of normal and transformed cell growth and that are mutated in approximately 30% of human cancers. Binding of ligands to various growth factor receptors activates Ras and subsequently a plethora of downstream effectors including the Raf-1/mitogen-activated protein kinase pathway. For effective ras functioning and for transformation, Ras proteins must undergo post-translational modifications that facilitate the...

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Publication status:
Published

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Journal:
Critical reviews in oncology/hematology
Volume:
44
Issue:
2
Pages:
109-120
Publication date:
2002-11-05
DOI:
EISSN:
1879-0461
ISSN:
1040-8428
URN:
uuid:56e85a2a-cc95-4c39-b381-472af78fde5e
Source identifiers:
319789
Local pid:
pubs:319789

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