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Journal article

Nuclear import of the influenza A virus transcriptional machinery.

Abstract:
Unusually for an RNA virus, influenza A viruses transcribe and replicate their genomes in the nuclei of infected cells. As a result the viral ribonucleoprotein complexes (RNPs), and their newly synthesised protein subunits, must interact with the host nuclear import machinery. In this review we discuss how the virus exploits nuclear import pathways to allow regulated and chaperoned assembly of RNPs in the nucleus, and describe how the import machinery itself can be a determinant of host tropism.
Publication status:
Published

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Authors


Hutchinson, EC More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Vaccine
Volume:
30
Issue:
51
Pages:
7353-7358
Publication date:
2012-12-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:56dd9aa3-b76e-409d-8ea2-2b4462d4506e
Source identifiers:
334697
Local pid:
pubs:334697

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