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Evolutionary cell biology of chromosome segregation: insights from trypanosomes.

Abstract:

Faithful transmission of genetic material is essential for the survival of all organisms. Eukaryotic chromosome segregation is driven by the kinetochore that assembles onto centromeric DNA to capture spindle microtubules and govern the movement of chromosomes. Its molecular mechanism has been actively studied in conventional model eukaryotes, such as yeasts, worms, flies and human. However, these organisms are closely related in the evolutionary time scale and it therefore remains unclear whe...

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Publication status:
Published

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Publisher copy:
10.1098/rsob.130023

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Open biology
Volume:
3
Issue:
5
Pages:
130023
Publication date:
2013-05-01
DOI:
EISSN:
2046-2441
ISSN:
2046-2441
Source identifiers:
401797
Language:
English
Keywords:
Pubs id:
pubs:401797
UUID:
uuid:56c947d3-28d9-43e1-af13-27af7484b315
Local pid:
pubs:401797
Deposit date:
2013-11-16

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