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Blockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischemia in adult rats.

Abstract:

The cytoprotective effect of NBQX, a selective AMPA receptor antagonist, was tested following 10 min of severe forebrain ischemia using the 4-vessel occlusion model. Immediately, and at 15 and 30 min following reperfusion, adult Wistar rats received intraperitoneal injections of either saline (n = 5), 1 mg lithium chloride (n = 17) or 30 mg/kg of the lithium salt of NBQX (n = 18). In saline-treated animals 82 +/- 12% of CA1 hippocampal neurons were lost. Of those treated with lithium 70 +/- 2...

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Publication status:
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Pulsinelli, WA More by this author
Journal:
Neuroscience letters
Volume:
132
Issue:
2
Pages:
255-258
Publication date:
1991-11-05
DOI:
EISSN:
1872-7972
ISSN:
0304-3940
URN:
uuid:56c2ab35-d92e-42e5-ad3f-d1fbe772b2d6
Source identifiers:
80173
Local pid:
pubs:80173

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