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Observed antibody space: a resource for data mining next generation sequencing of antibody repertoires

Abstract:

Abs are immune system proteins that recognize noxious molecules for elimination. Their sequence diversity and binding versatility have made Abs the primary class of biopharmaceuticals. Recently, it has become possible to query their immense natural diversity using next-generation sequencing of Ig gene repertoires (Ig-seq). However, Ig-seq outputs are currently fragmented across repositories and tend to be presented as raw nucleotide reads, which means nontrivial effort is required to reuse th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4049/jimmunol.1800708

Authors


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Institution:
University of Oxford
Department:
Interdisciplinary Bioscience DTP
Oxford college:
St Hugh's College
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Statistics
Snowden, J More by this author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Statistics
Oxford college:
Kellogg College
ORCID:
0000-0003-1388-2252
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Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
201
Issue:
8
Pages:
2502-2509
Publication date:
2018-10-15
Acceptance date:
2018-08-19
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Pubs id:
pubs:909536
URN:
uri:56c02308-eca0-4ac0-8cd5-3f4b9388aa7d
UUID:
uuid:56c02308-eca0-4ac0-8cd5-3f4b9388aa7d
Local pid:
pubs:909536

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