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Revealing mechanisms underlying variation in malaria virulence: effective propagation and host control of uninfected red blood cell supply.

Abstract:

Malaria parasite clones with the highest transmission rates to mosquitoes also tend to induce the most severe fitness consequences (or virulence) in mammals. This is in accord with expectations from the virulence-transmission trade-off hypothesis. However, the mechanisms underlying how different clones cause virulence are not well understood. Here, using data from eight murine malaria clones, we apply recently developed statistical methods to infer differences in clone characteristics, includ...

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Publication status:
Published

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Publisher copy:
10.1098/rsif.2012.0340

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Journal:
Journal of the Royal Society, Interface / the Royal Society
Volume:
9
Issue:
76
Pages:
2804-2813
Publication date:
2012-11-05
DOI:
EISSN:
1742-5662
ISSN:
1742-5689
URN:
uuid:56bb9f2c-4335-42d9-96dc-5dc87f7c2a96
Source identifiers:
359611
Local pid:
pubs:359611

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