Journal article icon

Journal article

A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme.

Abstract:

Amyloid diseases are characterized by an aberrant assembly of a specific protein or protein fragment into fibrils and plaques that are deposited in various organs and tissues, often with serious pathological consequences. Non-neuropathic systemic amyloidosis is associated with single point mutations in the gene coding for human lysozyme. Here we report that a single-domain fragment of a camelid antibody raised against wild-type human lysozyme inhibits the in vitro aggregation of its amyloidog...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/nature01870

Authors


Expand authors...
Journal:
Nature
Volume:
424
Issue:
6950
Pages:
783-788
Publication date:
2003-08-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:56b94006-8313-49d1-94e7-ea6cd4306e2a
Source identifiers:
59249
Local pid:
pubs:59249

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP