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Fluid dynamic characterization of a fluidized‐bed perfusion bioreactor with CFD–DEM simulation

Abstract:

BACKGROUND: In the recent development of regenerative medicine, the low yields of progenitor cells have limited the large-scale clinical applications. To overcome the limitation, a novel fluidized bed bioreactor has emerged. However, a detailed understanding of the fluid dynamics is still lacking.

RESULTS: A three-dimensional modelling approach that couples computational fluid dynamics (CFD) and discrete element method (DEM) was used to simulate the liquid and solid f...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1002/jctb.5576

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More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Oxford college:
Green Templeton College
Role:
Author
China Regenerative Medicine International More from this funder
Publisher:
Wiley Publisher's website
Journal:
Journal of Chemical Technology and Biotechnology Journal website
Volume:
93
Issue:
8
Pages:
2316-2330
Publication date:
2018-01-09
Acceptance date:
2018-01-04
DOI:
EISSN:
1097-4660
ISSN:
0268-2575
Pubs id:
pubs:820634
URN:
uri:56b4efca-4619-41c5-8cb7-9bbf25cc95ec
UUID:
uuid:56b4efca-4619-41c5-8cb7-9bbf25cc95ec
Local pid:
pubs:820634

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