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Journal article

Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites

Abstract:

Heterochromatin-dependent gene silencing is central to the adaptation and survival of Plasmodium falciparum malaria parasites, allowing clonally variant gene expression during blood infection in humans. By assessing genome-wide heterochromatin protein 1 (HP1) occupancy, we present a comprehensive analysis of heterochromatin landscapes across different Plasmodium species, strains, and life cycle stages. Common targets of epigenetic silencing include fast-evolving multi-gene families encoding s...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.chom.2018.01.008

Authors


Fraschka, SA More by this author
Filarsky, M More by this author
Niederwieser, I More by this author
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Publisher:
Elsevier Publisher's website
Journal:
Cell Host and Microbe Journal website
Volume:
23
Issue:
3
Pages:
407-420
Publication date:
2018-03-01
Acceptance date:
2018-01-16
DOI:
EISSN:
1934-6069
ISSN:
1931-3128
Pubs id:
pubs:828608
URN:
uri:56b47ac9-3f74-4218-86da-fdff5978df08
UUID:
uuid:56b47ac9-3f74-4218-86da-fdff5978df08
Local pid:
pubs:828608

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