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Journal article

Disambiguating pharmacological mechanisms from placebo in neuropathic pain using functional neuroimaging

Abstract:

Background
A lack of objective outcome measures and overreliance on subjective pain reports in early proof-of-concept studies contribute to the high attrition of potentially effective new analgesics. We studied the utility of neuroimaging in providing objective evidence of neural activity related to drug modulation or a placebo effect in a double-blind, randomized, placebo-controlled, three-way crossover trial.

Methods
We chronically adminis...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.bja.2017.11.064

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
ORCID:
0000-0003-4049-2364
Huggins, JP More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Vennart, W More by this author
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Medical Research Council More from this funder
Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
British Journal of Anaesthesia Journal website
Volume:
120
Issue:
2
Pages:
299–307
Publication date:
2018-02-07
Acceptance date:
2017-08-07
DOI:
Pubs id:
pubs:823052
URN:
uri:56b1308f-5942-4569-bc3f-f2a493a681c0
UUID:
uuid:56b1308f-5942-4569-bc3f-f2a493a681c0
Local pid:
pubs:823052

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