Disambiguating pharmacological mechanisms from placebo in neuropathic pain using functional neuroimaging
A lack of objective outcome measures and overreliance on subjective pain reports in early proof-of-concept studies contribute to the high attrition of potentially effective new analgesics. We studied the utility of neuroimaging in providing objective evidence of neural activity related to drug modulation or a placebo effect in a double-blind, randomized, placebo-controlled, three-way crossover trial.
We chronically adminis...
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- Peer reviewed
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- Wanigasekera et al
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- © 2017 Published by Elsevier Ltd on behalf of British Journal of Anaesthesia. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
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