- Abstract:
-
Protein tyrosine phosphatases PTPN5, PTPRR and PTPN7 comprise a family of phosphatases that specifically inactivate MAPKs (mitogen-activated protein kinases). We have determined high-resolution structures of all of the human family members, screened them against a library of 24000 compounds and identified two classes of inhibitors, cyclopenta[c]quinolinecarboxylic acids and 2,5-dimethylpyrrolyl benzoic acids. Comparative structural analysis revealed significant differences within this conserv...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1042/bj20051931
-
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- Journal:
- The Biochemical journal
- Volume:
- 395
- Issue:
- 3
- Pages:
- 483-491
- Publication date:
- 2006-05-05
- DOI:
- EISSN:
-
1470-8728
- ISSN:
-
0264-6021
- URN:
-
uuid:56af3859-6095-41b9-9338-ce6e5f296c02
- Source identifiers:
-
15869
- Local pid:
- pubs:15869
- Language:
- English
- Keywords:
- Copyright date:
- 2006
Journal article
Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
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