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Primary sclerosing cholangitis

Abstract:

Primary sclerosing cholangitis (PSC) is a chronic, cholestatic liver disease caused by diffuse inflammation and fibrosis that can involve the entire biliary tree. The progressive pathological process obliterates intrahepatic and extrahepatic bile ducts, ultimately leading to biliary cirrhosis, portal hypertension and hepatic failure. The cause is unknown but it is closely associated with inflammatory bowel disease, particularly ulcerative colitis which occurs in about 70% of cases. Approximat...

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Publisher copy:
10.1016/j.mpmed.2006.11.017

Authors


Chapman, RW More by this author
Journal:
Medicine
Volume:
35
Issue:
2
Pages:
83-85
Publication date:
2007-02-05
DOI:
ISSN:
1357-3039
URN:
uuid:56ad9b7e-b2ac-4140-9b30-c2a9f5d33c78
Source identifiers:
171743
Local pid:
pubs:171743

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