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Alteration in NMDA receptor subunit mRNA expression in vulnerable and resistant regions of in vitro ischemic rat hippocampal slices.

Abstract:

Brain insults, including cerebral ischemia, can alter glutamate receptor subunit expression in vulnerable neurons. Understanding these post-ischemic changes in glutamate receptors could enhance our ability to identify specific, novel neuroprotective compounds. Reverse transcription-polymerase chain reaction (RT-PCR) amplification was used to quantify the altered expression of the N-methyl-D-aspartate (NMDA) NR2A, NR2B and NR2C subunits relative to one another in rat hippocampal slices in resi...

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Publication status:
Published

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Authors


Poulter, MO More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Journal:
Neuroscience letters
Volume:
232
Issue:
2
Pages:
87-90
Publication date:
1997-08-05
DOI:
EISSN:
1872-7972
ISSN:
0304-3940
URN:
uuid:56a7e430-6fdf-4592-8f3f-1541d21073ef
Source identifiers:
79400
Local pid:
pubs:79400

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