Journal article icon

Journal article

Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells.

Abstract:

Gene-targeting studies have shown that Delta-like 4 (Dll4) is required for normal embryonic vascular remodeling, but the mechanisms underlying Dll4 regulatory functions are not well defined. We generated primary human umbilical vascular endothelial cells that express Dll4 protein to study Dll4 function and previously showed that Dll4 down-regulates vascular endothelial growth factor (VEGF) receptor 2 and NRP1 expression and inhibits VEGF function. We now report that expression of Dll4 in endo...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
Cancer research
Volume:
68
Issue:
6
Pages:
1889-1895
Publication date:
2008-03-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:56a31de4-e3b3-4862-8738-2bf4efdd29a3
Source identifiers:
125231
Local pid:
pubs:125231

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP