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Journal article

Synergistic activation of the human Btk promoter by transcription factors Sp1/3 and PU.1.

Abstract:

Analysis of the human Bruton's agammaglobulinemia tyrosine kinase (Btk) gene promoter revealed that 280 bp upstream of the transcriptional start site is sufficient for a cell restricted expression pattern. Here, the interplay of the transcription factors Sp1, Sp3, and PU.1 binding to this promoter area was analysed. All three proteins are able to independently activate the promoter in Drosophila Schneider (SL2) cells lacking endogenous Sp- or PU.1-like activities. Furthermore, PU.1 is able to...

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Publication status:
Published

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Publisher copy:
10.1006/bbrc.1999.0677

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Journal:
Biochemical and biophysical research communications
Volume:
259
Issue:
2
Pages:
364-369
Publication date:
1999-06-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:569e72d7-d1be-412e-b055-380590aca45d
Source identifiers:
374917
Local pid:
pubs:374917

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