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The regulatory protein RraA modulates RNA-binding and helicase activities of the E. coli RNA degradosome.

Abstract:

The Escherichia coli endoribonuclease RNase E is an essential enzyme having key roles in mRNA turnover and the processing of several structured RNA precursors, and it provides the scaffold to assemble the multienzyme RNA degradosome. The activity of RNase E is inhibited by the protein RraA, which can interact with the ribonuclease's degradosome-scaffolding domain. Here, we report that RraA can bind to the RNA helicase component of the degradosome (RhlB) and the two RNA-binding sites in the de...

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Publication status:
Published

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Publisher copy:
10.1261/rna.1858010

Authors


Górna, MW More by this author
Pietras, Z More by this author
Callaghan, AJ More by this author
Hernández, H More by this author
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Journal:
RNA (New York, N.Y.)
Volume:
16
Issue:
3
Pages:
553-562
Publication date:
2010-03-05
DOI:
EISSN:
1469-9001
ISSN:
1355-8382
URN:
uuid:5699d202-bd38-45ad-8d40-a6838c20a51b
Source identifiers:
59334
Local pid:
pubs:59334

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