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Journal article

Heterogeneity in myeloproliferative neoplasms: causes and consequences

Abstract:

Myeloproliferative neoplasms (MPNs) are haematopoietic stem cell-derived clonal disorders characterised by proliferation of some or all myeloid lineages, depending on the subtype. MPNs are classically categorized into three disease subgroups; essential thrombocythaemia (ET), polycythaemia vera (PV) and primary myelofibrosis (PMF). The majority (>85%) of patients carry a disease-initiating or driver mutation, the most prevalent occurring in the janus kinase 2 gene (JAK2 V617F), followed by ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jbior.2018.11.007

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM Clinical Laboratory Sciences
Oxford college:
Wolfson College
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM Clinical Laboratory Sciences
ORCID:
0000-0001-8522-1002
Publisher:
Elsevier Publisher's website
Journal:
Advances in Biological Regulation Journal website
Volume:
71
Pages:
55-68
Publication date:
2018-11-22
Acceptance date:
2018-11-20
DOI:
EISSN:
2212-4934
ISSN:
2212-4926
Pubs id:
pubs:953469
URN:
uri:569433d5-bd9a-4e29-afda-759c0cd6d54e
UUID:
uuid:569433d5-bd9a-4e29-afda-759c0cd6d54e
Local pid:
pubs:953469

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