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Journal article

Drosha regulates gene expression independently of RNA cleavage function.

Abstract:

Drosha is the main RNase III-like enzyme involved in the process of microRNA (miRNA) biogenesis in the nucleus. Using whole-genome ChIP-on-chip analysis, we demonstrate that, in addition to miRNA sequences, Drosha specifically binds promoter-proximal regions of many human genes in a transcription-dependent manner. This binding is not associated with miRNA production or RNA cleavage. Drosha knockdown in HeLa cells downregulated nascent gene transcription, resulting in a reduction of polyadenyl...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Cell reports
Volume:
5
Issue:
6
Pages:
1499-1510
Publication date:
2013-12-01
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Source identifiers:
444068
Language:
English
Keywords:
Pubs id:
pubs:444068
UUID:
uuid:568f69a1-4057-4cbb-9804-ce0f2ef944c5
Local pid:
pubs:444068
Deposit date:
2014-02-08

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