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TIMP-3 inhibits aggrecanase-mediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors.

Abstract:

Aggrecanases are considered to play a key role in the destruction of articular cartilage during the progression of arthritis. Here we report that the N-terminal inhibitory domain of tissue inhibitor of metalloproteinases 3 (N-TIMP-3), but not TIMP-1 or TIMP-2, inhibits glycosaminoglycan release from bovine nasal and porcine articular cartilage explants stimulated with interleukin-1alpha or retinoic acid in a dose-dependent manner. This inhibition is due to the blocking of aggrecanase activity...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
FEBS letters
Volume:
555
Issue:
3
Pages:
431-436
Publication date:
2003-12-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:568e5abe-a966-48de-9b04-9890193a67cd
Source identifiers:
226891
Local pid:
pubs:226891

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