Journal article
Targeted deletion of the Ncoa7 gene results in incomplete distal renal tubular acidosis in mice
- Abstract:
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We recently reported that nuclear receptor coactivator 7 (Ncoa7) is a vacuolar proton pumping ATPase (V-ATPase) interacting protein whose function has not been defined. Ncoa7 is highly expressed in the kidney and partially colocalizes with the V-ATPase in collecting duct intercalated cells (ICs). Here, we hypothesized that targeted deletion of the Ncoa7 gene could affect V-ATPase activity in ICs in vivo. We tested this by analyzing the acid-base status, major electrolytes, and kidney morpholo...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 16.8MB)
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- Publisher copy:
- 10.1152/ajprenal.00407.2017
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Authors
Funding
Bibliographic Details
- Publisher:
- American Physiological Society Publisher's website
- Journal:
- AJP - Renal Physiology Journal website
- Volume:
- 315
- Issue:
- 1
- Pages:
- F173-F185
- Publication date:
- 2018-07-01
- Acceptance date:
- 2018-01-27
- DOI:
- EISSN:
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1522-1466
- ISSN:
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1931-857X
- Pmid:
-
29384414
- Source identifiers:
-
822957
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:822957
- UUID:
-
uuid:567f4954-836f-41e5-81b9-8915227bb6ef
- Local pid:
- pubs:822957
- Deposit date:
- 2018-06-27
Terms of use
- Copyright holder:
- American Physiological Society
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 the American Physiological Society. This is the accepted manuscript version of the article. The final version is available online from American Physiological Society at: https://doi.org/10.1152/ajprenal.00407.2017
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