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Targeted deletion of the Ncoa7 gene results in incomplete distal renal tubular acidosis in mice

Abstract:

We recently reported that nuclear receptor coactivator 7 (Ncoa7) is a vacuolar proton pumping ATPase (V-ATPase) interacting protein whose function has not been defined. Ncoa7 is highly expressed in the kidney and partially colocalizes with the V-ATPase in collecting duct intercalated cells (ICs). Here, we hypothesized that targeted deletion of the Ncoa7 gene could affect V-ATPase activity in ICs in vivo. We tested this by analyzing the acid-base status, major electrolytes, and kidney morpholo...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1152/ajprenal.00407.2017

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Publisher:
American Physiological Society Publisher's website
Journal:
AJP - Renal Physiology Journal website
Volume:
315
Issue:
1
Pages:
F173-F185
Publication date:
2018-07-01
Acceptance date:
2018-01-27
DOI:
EISSN:
1522-1466
ISSN:
1931-857X
Pubs id:
pubs:822957
URN:
uri:567f4954-836f-41e5-81b9-8915227bb6ef
UUID:
uuid:567f4954-836f-41e5-81b9-8915227bb6ef
Local pid:
pubs:822957
Language:
English
Keywords:

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