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Patterns of osteocytic endothelial nitric oxide synthase expression in the femoral neck cortex: differences between cases of intracapsular hip fracture and controls.

Abstract:

Evidence indicates that extensive amalgamation of adjacent resorbing osteons is responsible for destroying the microstructural integrity of the femoral neck's inferior cortex in osteoporotic hip fracture. Such osteonal amalgamation is likely to involve a failure to limit excessive resorption, but its mechanistic basis remains enigmatic. Nitric oxide (NO) inhibits osteoclastic bone destruction, and in normal bone cells its generation by endothelial nitric oxide synthase (eNOS, the predominant ...

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Publication status:
Published

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Authors


Loveridge, N More by this author
Fletcher, S More by this author
Caballero-Alías, AM More by this author
Das-Gupta, V More by this author
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Journal:
Bone
Volume:
30
Issue:
6
Pages:
866-871
Publication date:
2002-06-05
DOI:
EISSN:
1873-2763
ISSN:
8756-3282
URN:
uuid:567d695d-6bc0-4d7d-8801-14212075f1ad
Source identifiers:
472477
Local pid:
pubs:472477

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