Phase variation is a mechanism of ON-OFF switching that is widely utilized by bacterial pathogens. There is currently no standardization to how the rate of phase variation is determined experimentally, and traditional methods of mutation rate estimation may not be appropriate to this process. Here, the history of mutation rate estimation is reviewed, describing the existing methods available. A new mathematical model that can be applied to this problem is also presented. This model specifical...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Mutation rates: estimating phase variation rates when fitness differences are present and their impact on population structure.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record