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Mutation rates: estimating phase variation rates when fitness differences are present and their impact on population structure.

Abstract:

Phase variation is a mechanism of ON-OFF switching that is widely utilized by bacterial pathogens. There is currently no standardization to how the rate of phase variation is determined experimentally, and traditional methods of mutation rate estimation may not be appropriate to this process. Here, the history of mutation rate estimation is reviewed, describing the existing methods available. A new mathematical model that can be applied to this problem is also presented. This model specifical...

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Publication status:
Published

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Publisher copy:
10.1099/mic.0.25807-0

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Microbiology (Reading, England)
Volume:
149
Issue:
Pt 2
Pages:
485-495
Publication date:
2003-02-05
DOI:
EISSN:
1465-2080
ISSN:
1350-0872
URN:
uuid:56786022-4d42-4742-8b08-bed7ea54c0aa
Source identifiers:
11585
Local pid:
pubs:11585

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