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pH-Dependence of extrinsic and intrinsic H(+)-ion mobility in the rat ventricular myocyte, investigated using flash photolysis of a caged-H(+) compound.

Abstract:

Passive H(+)-ion mobility within eukaryotic cells is low, due to H(+)-ion binding to cytoplasmic buffers. A localized intracellular acidosis can therefore persist for seconds or even minutes. Because H(+)-ions modulate so many biological processes, spatial intracellular pH (pH(i))-regulation becomes important for coordinating cellular activity. We have investigated spatial pH(i)-regulation in single and paired ventricular myocytes from rat heart by inducing a localized intracellular acid-load...

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Publication status:
Published

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Publisher copy:
10.1529/biophysj.106.096560

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
Journal:
Biophysical journal
Volume:
92
Issue:
2
Pages:
641-653
Publication date:
2007-01-05
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
URN:
uuid:56756164-1671-41b9-89c3-5921eba0f461
Source identifiers:
106467
Local pid:
pubs:106467

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