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Electroporation-mediated interleukin-10 overexpression in skeletal muscle reduces acute rejection in rat cardiac allografts.

Abstract:

OBJECTIVES: Human interleukin 10 (hIL-10) may reduce acute rejection after organ transplantation. Our previous data shows that electroporation-mediated transfer of plasmid DNA to peripheral muscle enhances gene transduction dramatically. This study was designed to investigate the effect of electroporation-mediated overexpression of hIL-10 on acute rejection of cardiac allografts in the rat. METHODS: The study was designed to evaluate the effect of hIL-10 gene transfer on (a) early rejection ...

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Publication status:
Published

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Publisher copy:
10.1002/jgm.859

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Journal:
The journal of gene medicine
Volume:
8
Issue:
2
Pages:
242-248
Publication date:
2006-02-05
DOI:
EISSN:
1521-2254
ISSN:
1099-498X
URN:
uuid:566b37c0-df0f-4015-a565-b6e40b348a13
Source identifiers:
246464
Local pid:
pubs:246464

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