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Down-regulation of the forkhead transcription factor Foxp1 is required for monocyte differentiation and macrophage function.

Abstract:

Down-regulation of the forkhead transcription factor Foxp1 by integrin engagement controls monocyte differentiation in vitro. To determine whether Foxp1 plays a critical role in monocyte differentiation and macrophage functions in vivo, we generated transgenic mice (macFoxp1tg) overexpressing human FOXP1 in monocyte/macrophage lineage cells using the CD68 promoter. Circulating blood monocytes from macFoxp1tg mice have reduced expression of the receptor for macrophage colony-stimulating factor...

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Publication status:
Published

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Authors


Mooroka, T More by this author
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Journal:
Blood
Volume:
112
Issue:
12
Pages:
4699-4711
Publication date:
2008-12-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:5667b775-e9de-4486-9618-82b95b69f1f6
Source identifiers:
27826
Local pid:
pubs:27826

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