- Abstract:
-
DC-SIGN, a C-type lectin expressed on dendritic cells (DCs), can sequester human immunodeficiency virus (HIV) virions in multivesicular bodies. Here, using large-scale gene expression profiling and tyrosine-phosphorylated proteome analyses, we characterized signaling mediated by DC-SIGN after activation by either HIV or a DC-SIGN-specific antibody. Activation of DC-SIGN resulted in downregulation of genes encoding major histocompatibility complex class II, Jagged 1 and interferon-response mol...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/ni1470
-
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- Journal:
- Nature immunology
- Volume:
- 8
- Issue:
- 6
- Pages:
- 569-577
- Publication date:
- 2007-06-05
- DOI:
- EISSN:
-
1529-2916
- ISSN:
-
1529-2908
- URN:
-
uuid:5665b00c-0d6d-4fb9-bff5-6054efa32243
- Source identifiers:
-
21461
- Local pid:
- pubs:21461
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication.
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