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Journal article

Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication.

Abstract:

DC-SIGN, a C-type lectin expressed on dendritic cells (DCs), can sequester human immunodeficiency virus (HIV) virions in multivesicular bodies. Here, using large-scale gene expression profiling and tyrosine-phosphorylated proteome analyses, we characterized signaling mediated by DC-SIGN after activation by either HIV or a DC-SIGN-specific antibody. Activation of DC-SIGN resulted in downregulation of genes encoding major histocompatibility complex class II, Jagged 1 and interferon-response mol...

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Publication status:
Published

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Publisher copy:
10.1038/ni1470

Authors


Sharrocks, K More by this author
Edelmann, M More by this author
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Journal:
Nature immunology
Volume:
8
Issue:
6
Pages:
569-577
Publication date:
2007-06-05
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
URN:
uuid:5665b00c-0d6d-4fb9-bff5-6054efa32243
Source identifiers:
21461
Local pid:
pubs:21461

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