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Permethrin pesticide induces NURR1 up-regulation in dopaminergic cell line: Is the pro-oxidant effect involved in toxicant-neuronal damage?

Abstract:

The mechanisms associated to the development of neurodegeneration due to pesticide exposure are not clear yet. In this study we evaluated how permethrin pesticide (PERM) can influence the Nurr1 gene and protein expression, and if a pro-oxidant activity of the pesticide contributes to up-regulation of Nurr1 in a dopaminergic cell line. Incubation of PC12 cells with 1μM PERM for 72h, leads to over expression of Nurr1 gene. This effect occurs with both corn oil and extra virgin olive oil (EVO) u...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.cbpc.2017.09.006

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Role:
Author
ORCID:
0000-0001-6968-1164
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Oxford college:
Wolfson College
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology Journal website
Volume:
201
Pages:
51-57
Publication date:
2017-09-22
Acceptance date:
2017-09-20
DOI:
EISSN:
1878-1659
ISSN:
1532-0456
Pubs id:
pubs:732988
URN:
uri:5644f457-1460-4cae-b504-b9d49b6ab484
UUID:
uuid:5644f457-1460-4cae-b504-b9d49b6ab484
Local pid:
pubs:732988
Language:
English
Keywords:

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