Journal article
Permethrin pesticide induces NURR1 up-regulation in dopaminergic cell line: Is the pro-oxidant effect involved in toxicant-neuronal damage?
- Abstract:
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The mechanisms associated to the development of neurodegeneration due to pesticide exposure are not clear yet. In this study we evaluated how permethrin pesticide (PERM) can influence the Nurr1 gene and protein expression, and if a pro-oxidant activity of the pesticide contributes to up-regulation of Nurr1 in a dopaminergic cell line. Incubation of PC12 cells with 1μM PERM for 72h, leads to over expression of Nurr1 gene. This effect occurs with both corn oil and extra virgin olive oil (EVO) u...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 737.8KB)
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- Publisher copy:
- 10.1016/j.cbpc.2017.09.006
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Authors
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology Journal website
- Volume:
- 201
- Pages:
- 51-57
- Publication date:
- 2017-09-22
- Acceptance date:
- 2017-09-20
- DOI:
- EISSN:
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1878-1659
- ISSN:
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1532-0456
- Pmid:
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28943456
- Source identifiers:
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732988
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:732988
- UUID:
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uuid:5644f457-1460-4cae-b504-b9d49b6ab484
- Local pid:
- pubs:732988
- Deposit date:
- 2018-06-22
Terms of use
- Copyright holder:
- Elsevier inc
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Elsevier Inc. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.cbpc.2017.09.006
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