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Journal article

Revisiting date and party hubs: novel approaches to role assignment in protein interaction networks

Abstract:

The idea of “date” and “party” hubs has been influential in the study of protein–protein interaction networks. Date hubs display low co-expression with their partners, whilst party hubs have high co-expression. It was proposed that party hubs are local coordinators whereas date hubs are global connectors. Here, we show that the reported importance of date hubs to network connectivity can in fact be attributed to a tiny subset of them. Crucially, these few, extremely central, hubs do not displ...

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M A Porter More by this author
Publication date:
2010
URN:
uuid:563c7b3d-8774-44fa-b614-e800a88ac5cd
Local pid:
oai:eprints.maths.ox.ac.uk:1811

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