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The RAS signal transduction pathway and its role in radiation sensitivity.

Abstract:

RAS has been shown to increase radiation resistance. Upstream and downstream pathways from RAS could thus be targets for manipulation of radiosensitivity. EGFR expression and AKT phosphorylation are also associated with the response to radiation. A retrospective study evaluating EGFR and AKT in patients treated with multimodality therapy found a significant association between P-AKT and treatment failure. Moreover, these data are strengthened by in vitro studies showing that inhibition of EGF...

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Publication status:
Published

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Publisher copy:
10.1038/sj.onc.1206699

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Bernhard, EJ More by this author
Journal:
Oncogene
Volume:
22
Issue:
37
Pages:
5866-5875
Publication date:
2003-09-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:563bffb3-9166-49a0-8f8a-2524a85cb8f6
Source identifiers:
118195
Local pid:
pubs:118195

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