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Journal article

Tolerance and suppression in a primed immune system.

Abstract:

The induction of tolerance in a primed immune system would be valuable therapeutically, but has been difficult to achieve. Mice primed to multiple minor histoincompatible antigens (minors) are able to rapidly reject secondary grafts using either their CD4+ or CD8+ T-cell subpopulations. Short courses of treatment with nonlytic anti-CD4 and anti-CD8 antibodies targeted at both T-cell subsets can induce long-term peripheral T-cell tolerance in primed mice. We examine the mechanisms by which per...

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Publication status:
Published

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Authors


Marshall, SE More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Davies, JD More by this author
Martin, GM More by this author
Phillips, JM More by this author
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Journal:
Transplantation
Volume:
62
Issue:
11
Pages:
1614-1621
Publication date:
1996-12-05
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
URN:
uuid:563bfb1e-b720-44d6-a3fc-c7f8948f229b
Source identifiers:
25449
Local pid:
pubs:25449

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