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Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression.

Abstract:

Recruitment of CCR2(+)Ly6C(high) monocytes to sites of infection is essential for efficient clearance of microbial pathogens. Although CCR2-mediated signals promote monocyte emigration from bone marrow, the contribution of CCR2 to later stages of monocyte recruitment remains unresolved. In this article, we show that CCR2 deficiency markedly worsens hepatic Listeria monocytogenes infection because Ly6C(high) monocytes are retained in the bone marrow. Intravenously transferred, CCR2-deficient L...

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Publisher copy:
10.4049/jimmunol.0904160

Authors


Velázquez, P More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
184
Issue:
11
Pages:
6266-6274
Publication date:
2010-06-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:56319cd2-431b-4866-b072-a4172b96ca0a
Source identifiers:
426283
Local pid:
pubs:426283

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