Journal article icon

Journal article

Four base recognition by triplex-forming oligonucleotides at physiological pH.

Abstract:

We have achieved recognition of all 4 bp by triple helix formation at physiological pH, using triplex-forming oligonucleotides that contain four different synthetic nucleotides. BAU [2'-aminoethoxy-5-(3-aminoprop-1-ynyl)uridine] recognizes AT base pairs with high affinity, (Me)P (3-methyl-2 aminopyridine) binds to GC at higher pHs than cytosine, while (A)PP (6-(3-aminopropyl)-7-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one) and S [N-(4-(3-acetamidophenyl)thiazol-2-yl-acetamide)] bind to CG and ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1093/nar/gki625

Authors


Expand authors...
Journal:
Nucleic acids research
Volume:
33
Issue:
9
Pages:
3025-3032
Publication date:
2005-01-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:562daae7-42cd-4361-8318-d107866e679e
Source identifiers:
400043
Local pid:
pubs:400043

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP