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Journal article

Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2'-hydroxyphenyl)benzoxazole analogs of UK-1.

Abstract:

UK-1 is a bis(benzoxazole) natural product displaying activity against a wide range of human cancer cell lines. A simplified analog of UK-1, 4-carbomethoxy-2-(2'-hydroxyphenyl)benzoxazole, was previously found to be almost as active as UK-1 against cancer cell lines, and similar to the natural product, formed complexes with a variety of metal ions such as Mg2+ and Zn2+. A series of 4-substituted-2-(2'-hydroxyphenyl)benzoxazole analogs of this 'minimal pharmacophore' of UK-1 were prepared. The...

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Publication status:
Published

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Publisher copy:
10.1016/j.bmc.2007.11.019

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics
Kerwin, SM More by this author
Journal:
Bioorganic and medicinal chemistry
Volume:
16
Issue:
4
Pages:
1775-1783
Publication date:
2008-02-05
DOI:
EISSN:
1464-3391
ISSN:
0968-0896
URN:
uuid:56293d42-6168-40ee-8fbf-7c11770f50d7
Source identifiers:
181383
Local pid:
pubs:181383

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