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Factors influencing retention of adenovirus within tumours following direct intratumoural injection.

Abstract:

Direct intratumoural (IT) administration of adenovirus is widely used, however little is known about the resulting distribution of virus particles. Here we have evaluated the influence of tumour size, volume of injectate and occlusion of injection sites (to prevent retrograde seepage) on particle biodistribution and transgene expression. In subcutaneous MDA-231 xenografts, IT injection of relatively large volumes (4 x 20% (vol/vol) injections) resulted in just 40% of the administered dose bei...

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Publication status:
Published

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Publisher copy:
10.1038/gt.2008.2

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Institution:
University of Oxford
Department:
Oxford, MPLS, Engineering Science
Role:
Author
Journal:
Gene therapy
Volume:
15
Issue:
9
Pages:
688-694
Publication date:
2008-05-05
DOI:
EISSN:
1476-5462
ISSN:
0969-7128
URN:
uuid:56285198-4cd5-4489-b9f4-5774ed784373
Source identifiers:
178612
Local pid:
pubs:178612

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