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Detection of specific antibodies to HCV-ARF/CORE+1 protein in patients treated with pegylated interferon plus ribavirin

Abstract:

Hepatitis C virus (HCV) infection is a major cause for chronic liver disease and hepatocellular carcinoma. The HCV-ARF/core+1 protein is an alternative product of HCV core-encoding sequence of unknown biological function. Highly purified HCV core and ARF/core+1 recombinant proteins from HCV genotype 1a and HCV-ARF/core+1 recombinant protein from HCV genotype 3a were expressed in Escherichia coli. Using an enzyme-linked immunosorbent assay, we assessed the prevalence of anti-ARF/core+1 antibod...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
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Publisher:
Wiley Publisher's website
Journal:
Journal of Viral Hepatitis Journal website
Volume:
19
Issue:
3
Pages:
182–188
Publication date:
2011-10-04
Acceptance date:
2011-04-01
DOI:
ISSN:
1365-2893 and 1352-0504
Pmid:
22329372

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