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Naturally acquired antibodies to polymorphic and conserved epitopes of Plasmodium falciparum merozoite surface protein 3.

Abstract:

Many studies on the role of merozoite surface protein 3 (MSP3) in immunity against malaria have focused on a conserved section of MSP3. New evidence suggests that polymorphic sequences within MSP3 are under immune selection. We report a detailed analysis of naturally-acquired antibodies to allele-specific and conserved parts of MSP3 in a Kenyan cohort. Indirect and competition ELISA to heterologous recombinant MSP3 proteins were used for antibody assays, and parasites were genotyped for msp3 ...

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Publication status:
Published

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Journal:
Parasite immunology
Volume:
29
Issue:
8
Pages:
387-394
Publication date:
2007-08-05
DOI:
EISSN:
1365-3024
ISSN:
0141-9838
URN:
uuid:561bd9c7-11e9-467d-a220-8ddd2e333f3b
Source identifiers:
140095
Local pid:
pubs:140095

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