Naturally acquired antibodies to polymorphic and conserved epitopes of Plasmodium falciparum merozoite surface protein 3.

Journal article

Many studies on the role of merozoite surface protein 3 (MSP3) in immunity against malaria have focused on a conserved section of MSP3. New evidence suggests that polymorphic sequences within MSP3 are under immune selection. We report a detailed analysis of naturally-acquired antibodies to allele-specific and conserved parts of MSP3 in a Kenyan cohort. Indirect and competition ELISA to heterologous recombinant MSP3 proteins were used for antibody assays, and parasites were genotyped for msp3 ...

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Authors: Osier, F; Polley, S; Mwangi, T; Lowe, B; Conway, D

• Publication status: Published
• Journal: Parasite immunology
• Volume: 29
• Issue: 8
• Pages: 387-394
• Publication date: 2007-08-01
• DOI: 10.1111/j.1365-3024.2007.00951.x
• EISSN: 1365-3024
• ISSN: 0141-9838
• Language: English
• Keywords: Longitudinal Studies; Humans; Epitopes; Antibodies, Protozoan; Enzyme-Linked Immunosorbent Assay; Animals; Recombinant Fusion Proteins; Immunoglobulin G; Antigens, Protozoan; Malaria, Falciparum; Plasmodium falciparum; Cohort Studies; Protozoan Proteins; Kenya; Alleles