Combined quantitative and mechanistic study of drug-membrane interactions using a novel 2H NMR approach.
Several analytical methods are available for determining the partition coefficients of drug compounds in model phospholipid membranes, but such methods provide little information at the molecular level about how the membrane affinity of drugs relates to their interactions with the lipid molecules. A new (2)H nuclear magnetic resonance (NMR) approach has been developed here that quantifies the affinity of (2)H-labeled small molecules for different phospholipid membranes and, simultaneously, pr...Expand abstract
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