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Gene gun intradermal DNA immunization followed by boosting with modified vaccinia virus Ankara: enhanced CD8+ T cell immunogenicity and protective efficacy in the influenza and malaria models.

Abstract:

In influenza and malaria, CD8+ T cells play an important role in protective immunity in mice. An immunization strategy consisting of DNA priming followed by boosting with recombinant modified vaccinia virus Ankara (MVA) induces complete protection, associated with high levels of CD8+ T cells, against Plasmodium berghei sporozoite challenge in mice. Intradermal delivery of DNA with a gene gun requires smaller amounts of DNA than intramuscular injection, in order to induce similar levels of imm...

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Publication status:
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Authors


Dégano, P More by this author
Schneider, J More by this author
Hannan, CM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Journal:
Vaccine
Volume:
18
Issue:
7-8
Pages:
623-632
Publication date:
1999-11-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:5618c305-5500-472f-946d-10be64e0fa65
Source identifiers:
31569
Local pid:
pubs:31569

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