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Prostaglandin E2 signaling through E prostanoid receptor 2 impairs proliferative response of double negative regulatory T cells.

Abstract:

Limited data are available on the mechanisms that constrain the function of regulatory populations of T cells. Prostaglandin E2 (PGE2) is an endogenous membrane phospholipid metabolite that has important immunomodulatory effects on T cell function. Our previous microarray data indicated that E prostanoid receptor 2 (EP2), a receptor for PGE2, is expressed by regulatory alphabetaTCR(+) CD4(-) CD8(-) NK1.1(-) double negative T (DN Treg) cell clones but not by their non-regulatory natural mutant...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Role:
Author
Journal:
International immunopharmacology
Volume:
9
Issue:
5
Pages:
534-539
Publication date:
2009-05-05
DOI:
EISSN:
1878-1705
ISSN:
1567-5769
URN:
uuid:56176559-43d9-46aa-b339-b6baa9758886
Source identifiers:
400594
Local pid:
pubs:400594

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